Hi Jeremy,
Well, that sort of helps. I hesitate to get into much detail in a public forum because this is work in progress but suffice it to say that I'd like to use the same methods for deriving the coefficients that you do on a different set of data. I've done the initial fitting step (using a robust fitting routine based on poly_fit rather than svd) and have the Type II regression results; what I don't understand (or know how to implement) is the iterative step of the slope/adjustment process. It would really help just to have an idea (even in general terms) about how you approach that (I could not find anything specific in T/M Vol. 11 - if its there, I've been missing it). I can sort of imagine developing a cost function based on the difference between 1 and the regression slope combined with the difference between 0 and the intercept, but are they weighted in some way? combined? Maybe the best I can do is offer to be an external reviewer of the forthcoming ATBD

. Anyway, thanks for the reply. After not hearing any response to my initial query I was worried that the answer to my question was so obvious that I shouldn't have asked.
Best, Barry